Kate Hughes

PhD Student


Prof. Annette Karmiloff-Smith

Dr. Emma Meaburn

Research Interests

I am interested in the link between Down syndrome and Alzheimer's in children aged 4 to 16 years. I am a PhD student working as part of the CBCD and LonDownS consortium. In my MSc project, I researched the affect of TREM2 variants on pathology in Alzheimer's disease via microglial activation in brain regions, and in my BSc I researched the controversies in determining causes of neurodegeneration. Drawing on previous research and experience I am now studying the link between a genetic, developmental phenotypically diverse condition, and an adult, late-onset degenerative disease.

Specifically, my project is looking at risk and protective features in Down syndrome related to subsequent possible Alzheimer's disease. I am looking at children aged 4 to 16, and analysing behavioural, cognitive and neural traits, along with specific genetic individual differences. Hopefully the results of this study will enable earlier identification of individuals who are at risk of developing Alzheimer's. This will enable an earlier and better intervention to reduce onset and severity of neurodegeneration, both in Down syndrome and typically developing individuals.

If you have any questions about my project, or would like to be involved please contact me at khughe05@mail.bbk.ac.uk or kmohughes.89@gmail.com


PhD Clinical Psychology 

Birkbeck, University of London

2013 - Present 

MSc Clinical Neuroscience (merit)


2012 - 2013

BSc (Hons Neuroscience) Biological Sciences (2.1) 

University of Edinburgh

2008 - 2012

Scholarships and awards:

2013-2016 College Research Studentship as a Fee Waiver