Prof. Annette Karmiloff-Smith
Dr. Emma Meaburn
I am interested in the link between Down syndrome and Alzheimer's in children aged 4 to 16 years. I am a PhD student working as part of the CBCD and LonDownS consortium. In my MSc project, I researched the affect of TREM2 variants on pathology in Alzheimer's disease via microglial activation in brain regions, and in my BSc I researched the controversies in determining causes of neurodegeneration. Drawing on previous research and experience I am now studying the link between a genetic, developmental phenotypically diverse condition, and an adult, late-onset degenerative disease.
Specifically, my project is looking at risk and protective features in Down syndrome related to subsequent possible Alzheimer's disease. I am looking at children aged 4 to 16, and analysing behavioural, cognitive and neural traits, along with specific genetic individual differences. Hopefully the results of this study will enable earlier identification of individuals who are at risk of developing Alzheimer's. This will enable an earlier and better intervention to reduce onset and severity of neurodegeneration, both in Down syndrome and typically developing individuals.
PhD Clinical Psychology
Birkbeck, University of London
2013 - Present
MSc Clinical Neuroscience (merit)
2012 - 2013
BSc (Hons Neuroscience) Biological Sciences (2.1)
University of Edinburgh
2008 - 2012
Scholarships and awards:
2013-2016 College Research Studentship as a Fee Waiver